Festival dijadwalkan dari 11 Mar hingga 20 Mar 2022 (9 hari).
South By Southwest (SXSW) berlangsung di Austin, United States. Berikut adalah alamat lengkap festival: Austin Convention Center, Austin, TX, US 78701
Shawn Mendes, Sebastián Yatra, Kygo, Flogging Molly, Don Toliver, Sheryl Crow, Buddy Guy, KT Tunstall, Beck, Lauren Jauregui, Young Thug, Anavitória, Dolly Parton, The Warning, Matt Maeson, Japanese Breakfast, Gunna, Weyes Blood, Houndmouth, T‐Pain, Spoon, Perfume Genius, Mayhem, The Black Angels, Baroness, Paul Wall, Kishi Bashi, Ezra Furman, The Lathums, Russkaja, Sheck Wes, High on Fire, Jamie Webster, NOVA TWINS, Muna, CHAI, John Moreland, Pussy Riot, The Lemonheads, Black Lips, New Candys, Cymande, Twin Tribes, Delta Spirit, Kristin Hersh, Zola Jesus, Heartless Bastards, Gang of Four, Babyface Ray, Best Coast.
Genre dan sub-genre yang paling populer dari edisi sebelumnya adalah:
rock
folk
pop
indie
alternative
indie rock
indie pop
alternative rock
experimental
psychedelic
americana
lo-fi
acoustic
folk rock
post-punk
metal
punk rock
garage rock
psychedelic rock