Festival dijadwalkan dari 12 Mei hingga 14 Mei 2022 (2 hari).
The Great Escape berlangsung di Brighton, United Kingdom. Berikut adalah alamat lengkap festival: Brighton and Hove, England
Alfie Templeman, Muna, The Amazons, Jada, Wild Rivers, Pip Millett, Dea Matrona, Porches, Newen Afrobeat, Indigo De Souza, Ilira, Dead Sara, Elles Bailey, Yours Truly, Alex the Astronaut, Bears In Trees, Kid Kapichi, Penguin Cafe, Mild Orange, Yard Act, Mykki Blanco, Rebecca Black, The Vanns, BC Camplight, Crawlers, Stone, Jonathan Bree, Will Joseph Cook, Lil Mariko, Namasenda, Warmduscher, Eloise, Lunar Vacation, spill tab, Douglas Dare.
Genre dan sub-genre yang paling populer dari edisi sebelumnya adalah:
rock
electronic
pop
indie
alternative
indie pop
indie rock
hardcore
acoustic
dance
metal
ambient
emo
experimental
hardcore punk
house
indie folk
piano
power metal