Festival dijadwalkan dari 10 Jun hingga 13 Jun 2010 (3 hari).
Bonnaroo Music Festival berlangsung di Manchester, United States. Berikut adalah alamat lengkap festival: Great Stage Park, Manchester, Tennessee, U.S
Zac Brown Band, Dropkick Murphys, Weezer, Kings of Leon, The Black Keys, Norah Jones, John Fogerty, Rise Against, Brandi Carlile, Miranda Lambert, Dave Matthews Band, Tenacious D, Frank Turner, Kid Cudi, John Butler Trio, Rebelution, deadmau5, Clutch, The National, The Avett Brothers.
Genre dan sub-genre yang paling populer dari edisi sebelumnya adalah:
rock
folk
pop
indie
alternative
indie rock
alternative rock
americana
folk rock
indie pop
acoustic
electronica
dance
indie folk
electro
experimental
bluegrass
comedy
hard rock